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doi: 10.1038/s41467-020-17181-w 55 ZhiweiYTaiyanYXuWKelinMTianlaiWBoyuWet al

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The substantial increase in plasma bile acid concentrations (primary, secondary, total and unconjugated bile acid concentrations) with metformin may be explained by the fact that metformin increased the abundance of probiotic bacteria, especially Lactobacillus , and thus their bile salt hydrolase (BSH) gene expression