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So if something goes wrong and the GSSG accumulates, it inhibits an enzyme that relies on the correct oxidation of the ER environment to operate a protein quality control system. Moreover, they discovered, when misfolded proteins dont pass quality control, they wont get exported, so they too pile up in the ER

From 23 rd June the first very small cohort of patients can access this treatment

Metabolism of Pancreatic Cancer: Paving the Way to Better Anticancer Strategies