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Zepbound is a dual GIP and GLP-1 receptor agonist)

NAC (Sigma-Aldrich, A7250) was diluted in drinking water at a concentration of 30 mM, the pH was adjusted to 7.00 and it was provided to mice ad libitum

[DOI] [PMC free article] [PubMed] [Google Scholar] 55.A review of GLP-1 receptor agonists: Evolution and advancement, through the lens of randomised controlled trials

Specifically, they suppress the production of key pro-inflammatory mediatorsincluding IL-1, IL-6, and iNOSin a concentration-dependent manner, while concurrently upregulating anti-inflammatory markers such as transforming growth factor-beta (TGF-) and arginase-1 (Arg1) ( In experimental spinal cord injury models, GLPs preserve myelin ultrastructure and enhance functional recovery through multimodal neuroprotective actions: they suppress neuronal and oligodendroglial apoptosisevidenced by reduced caspase-3 cleavageattenuate neuroinflammation via downregulation of TNF- and myeloperoxidase (MPO) activity, and counteract oxidative damage by decreasing MDA and NO levels while boosting SOD activity