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There are also 21 letters in each of those themed answers, and further references to 21 in several other clues: 22A

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The United States and Canada had one of the highest rates of cannabis, opioid, and cocaine dependence (748.7, 650.0, and 301.2 per 100,000 people, respectively). Australasia had the highest prevalence of amphetamine dependence (491.5 per 100,000 people), as well as high rates of cannabis, opioid and cocaine use dependence (693.7, 509.9, and 160.5 per 100,000 people, respectively). Some countries and regions (e.g., Africa, Caribbean and Latin America, Asia regions) have little or no data on substance use and associated health burden

The streamlined silhouette offers a refined look while the bengaline fabric ensures all-day comfort with just the right amount of structure

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