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Nanoparticles were designed with a 2,2-(propane-2,2-diylbis(sulfanediyl)) bis(ethan-1-ol) linker that could be oxidized by ROS, decompose into oligomeric units, and release the ruthenium catalyst

Together, this combination aims to mimic the body's natural secretion of GH (both baseline and pulses), potentially enhancing anabolic effects, recovery, and tissue repair

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Its clinical program in the late 2000s was built around large, rigorously controlled trials with a hard imaging endpoint (visceral adipose tissue measured by CT), and it culminated in FDA approval in 2010

But the glucagon component adds something Mounjaro cannot: increased energy output