Therefore, EBV may be involved in the brain-gut-microbiota axis communication in MS through various mechanisms, including affecting gut microbiota composition and metabolites, inducing an inflammatory microenvironment in the gut, damaging the intestinal barrier and influencing the phenotypes of immune cells in the gut and CNS by cooperating and antagonizing with the bacteria
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While a prior study reported that IL-24 induces EMT in bronchial epithelial cells 21 , we found that IL-24 also promotes the production of profibrotic factors such as amphiregulin and GM-CSF