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An orally active allosteric GLP-1 receptor agonist is neuroprotective in cellular and rodent models of stroke

Furthermore, the infiltration of IL-1- and TNF--positive macrophages detected in the spinal cord of sporadic ALS patients but not in controls [28] might possibly explain the low levels of these cytokines observed in the sera of our ALS patients

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Challenges include the high cost of production, protracted clinical trial timelines, and the stringent safety and regulatory requirements that must be met

Loss of the nuclear receptor corepressor SLIRP compromises male fertility