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Recently, our group has demonstrated that PD mimetics including 6-hydroxydopamine (6-OHDA), N-methyl-4-phenylpridine (MPP + ) and rotenone suppressed mTOR signalling, accelerated cleavage of caspase-3 and PARP in PC12 cells and primary neurons and subsequently triggered neuronal apoptosis

In a survey that drew responses from nearly 28,000 people taking these drugs, weight loss ranged from modest to dramatic

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There is much interest in its clinical application in various neural disorders such as Alzheimer's disease and painful neuropathies [114]