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It is also necessary to clarify the interconnectivity between disparate pathways within the internal milieu of the mitochondrial quality control system, to analyze the role of mitochondria and neurons in modulating the functionality of the brain and central nervous system, and to propose novel concepts and methodologies for the early diagnosis, prevention, and treatment of neurodegenerative diseases

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In 2016, Gao et al

The copper-peptide coordination depends on specific pH ranges