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Therefore, it is recommended that IGF-1 levels remain within the upper normal range (+1 to +2 SDS) for age-matched normal children during GH therapy, and it is indicated in infants and children with PWS to start therapy with a daily dose of 0.5 mg/m2 per day to minimize side effects, with subsequent adjustments toward 1.0 mg/m2 per day (117)

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When combined with fibroblast growth factors (FGFs), which bind to receptors in the presence of heparin, causing endothelial cell migration, VEGF-A levels increase, leading to stabilization and growth of new vessels (Claire and Larrive 2017