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Our results support the argument that the nicotine-derived DNA adducts are likely the main causes for carcinogenesis in mice exposed to e-cigarette smoke, says study author Herbert Lepor, MD, the Martin Spatz Chair in the Department of Urology at NYU Langone

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Approximately 46% of NNN and 26%-37% of NNK in tobacco is preformed and the remainder is pyrosynthesized from nicotine during smoking (36)