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If intranasal delivery achieves preferential brain delivery at the expense of systemic exposure, the hepatic glucagon receptor activation would be reduced
Obesity Clinical Development Pipeline MoA Abbreviations: GLP-1 RA GLP-1 receptor agonist(s)
Mechanistically, GLP-1s are thought to cross the blood-brain barrier and act directly on the brain, potentially reducing neuroinflammation, improving insulin signaling, and altering amyloid and tau pathology
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