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Apparently, FSP1 provides another important pathway for ferroptosis that is not limited to mitochondria ( GCH1 To identify other ways to regulate ferroptosis sensitivity, a new set of ferroptosis inhibition genes was identified by genome-wide activation library screening

Mitchell JR, Jollow DJ, Potter WZ, Gillette JR, Brodie BB

Renal proximal tubule cells specifically maintain high intracellular glutathione levels because they are metabolically active and handle a disproportionate share of the body's reabsorption and detoxification work

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