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In initial preclinical studies, orforglipron has been shown to stimulate insulin secretion and reduce food consumption in non-human primates, and it is fully efficacious at lowering hyperglycemia in mice expressing the human GLP-1R but inactive in GLP-1R knockout animals

doi:10.1161/CIR.0000000000001239

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Add cauliflower rice and cook for 5 minutes until tender

The study included health records for 11,681 adults with Type 2 diabetes who had a moderate or high risk score as determined by the 10-year Atherosclerotic Cardiovascular Disease (ASCVD) risk score, a standardized cardiovascular disease calculator outlined in a 2018 special report from the American Heart Association and the American College of Cardiology