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Although extending the half-life of NO may indeed be one of the functions and mechanisms of action of SNOs, it has been shown repeatedly that the amount of NO released does not sufficiently account for their total biological activity (52,53,182)

Filipek PA, Juranek J, Smith M, Mays LZ, Ramos ER, Bocian M, et al

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The clinically most important application of this knowledge has been the use of ablative or stimulation treatment applied to the basal ganglia motor circuit as treatment for hypo- and hyperkinetic disorders [44]