The expression level of the gene in the wild-type (CO23) or resistant (CO23RFK and CO23RFLC) strains, treated or untreated with FLC or MCFG, are represented as n-fold increase or decrease relative to the level of the untreated control strain (CO23)
In addition to the physiological role of receptor-mediated transcytosis, such as the brain delivery of leptin via leptin receptors (35), the phenomenon has been harnessed for the delivery of drugs across the BBB and is considered as one of the most promising brain drug delivery strategies
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Additionally, it appears to alleviate neuroinflammation by inhibiting the NF-B pathway (Du et al., 2019), restore dopamine levels and increase BDNF expression (Lee et al., 2013), and even enhance hippocampal neurogenesis through the cAMP/PKA pathway (Zhang et al., 2018)
Measurement: Food