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In addition to well-known terms, there were also associations with terms related to fatty liver disease (ADIPOQ, AKT1, ALB, DPP4, FGF21, FOXO1, GCG, INS, IRS1, IRS2, LEP, LEPR, PPARA, PPARG, PPARGC1A), chemokine signaling, and sirtuin interactome
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The observation that the insulinotropic actions of GLP-1 are reduced in type 2 diabetes mellitus (T2DM) led to the development of incretin-based therapies GLP-1 receptor agonists and dipeptidyl peptidase 4 (DPP-4) inhibitors for the treatment of hyperglycaemia in these patients
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