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Viral protein nsp12 (RNA-dependent RNA polymerase) could sense host nucleotide availability and modulate replication efficacy of the viral genome 36

Protein oxidation is another critical mechanism where free radicals modify amino acid side chains, form protein-protein cross-links, and fragment peptide chains

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Therefore, conjugation with GSH is an important protective mechanism against reactive electrophilic xenobiotics, such as environmental pollutants, chemical carcinogens, antitumor agents (adriamycin, busulfan, chlorambucil, c/s-platin, cyclophosphamide, ethacrynic acid) preventing their covalent binding to proteins