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Based on this, rutin can upregulate the cell adhesion molecule-1 (CD31) and vascular endothelial-cadherin (VE-cadherin) expression levels, while downregulating the -SMA and collagen 1 expression levels, alleviating EMT through elevating LC3B II/LC3B I ratio and beclin 1 expression and restoring autophagy in db/db mice and HG-treated GEnC (Dong et al., 2023)
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Nutrex Liquid L-Carnitine 3000 Nutrex Liquid L-Carnitine 3000 $19.99 / products.product.pickup_availability.unavailable Your payment information is processed securely
In addition to these widely used AOMs, Exenatide, one of the earliest GLP-1 RAs approved by the FDA and EMA for T2DM management, is not indicated for weight management but remains clinically relevant, particularly in older adults with comorbid obesity and T2DM, given its long-term clinical experience and established tolerability profile [26,27,28]
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