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The ligand is selected according to the nature of the target molecules and is bound to the solid support

The liver also relies on its enzymatic antioxidant system, which includes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)

Both methods of administration have advantages and disadvantages, and the choice is influenced by factors such as personal preferences, treatment objectives, and medical concerns

Keywords: Alcohol binge drinking, Glutathione, Glutathion-S-transferase-Pi, Oxidative stress, Protein S-glutathionylation, ROS INTRODUCTION The liver plays a central role in metabolizing alcohol, with chronic alcohol consumption increasing the risk of liver diseases, such as fatty liver, hepatitis, and cirrhosis (Contreras-Zentella et al ., 2022)