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Future research should focus on identifying biomarkers to guide personalized management and conducting rigorous, long-term comparative studies to determine the most effective therapeutic strategies for this subset of patients

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Medications like anticoagulants/antiplatelets, cyclosporine, and any medication changed by the liver (like cytochrome P450 3A4), are also not recommended with berberine

Excessive activation of B and T lymphocytes leads to a significant increase in total hydrogen peroxide concentration, which will further lead to thyrocyte necrosis and apoptosis ( 4.2 Oxidative stress in PCOS Oxidative stress plays a very important role in the etiology of PCOS

Dose-Response Curve or Death-Response Curve