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Conclusion Managing a cobalt allergy while ensuring adequate Vitamin B12 intake is challenging but achievable

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Population studies taking into account basal, absolute, and net increases of postmethionine-load homocysteine levels, in relation to dietary intake and methionine, folate, and status of vitamins B 6 and B 12 to confirm the involvement of methionine excess in both basal and postload hyperhomocysteinemia

The tests were carried out with daily doses of 2000 to 6000 mg for periods between one and 28 days