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in contrast, methadone and the selective peptide agonist [D-Ala 2 , N-Me-Phe 4 , Gly 5 -ol]-enkephalin (DAMGO) produce marked receptor endocytosis with little tolerance [21,88,91,92,93]

Effects of growth hormone-releasing peptide-6 on the nocturnal secretion of GH, ACTH and cortisol and on the sleep EEG in man: role of routes of administration

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[1] [2] Some patients may benefit from extending the time between dose increases if gastrointestinal symptoms are problematic