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[41] This can change when blood vessels are damagedfor example by physical injury, or rupture, or atherosclerotic plaque

The expression of cholesterol content and cholesterol metabolism-related molecules such as Sterol Regulatory Element-Binding Protein 2 (SREBP2), 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR), ATP Binding Cassette Transporter A1 (ABCA1), and ATP Binding Cassette Transporter G1 (ABCG1) were detected by cholesterol assay kits and immunohistochemistry (IHC) in vivo, and were detected by cholesterol assay kits, Western blot (WB), and quantitative real-time polymerase chain reaction (Q-PCR) in vitro

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In this system, small farmers described selling tobacco to a central farmer or leader in the village, or a local buyer, who would pool tobacco from many small producers and sell it to warehouses owned by local businessmen or by larger national or multinational companies purchasing tobacco leaf