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TDG facilitates the active demethylation of the GS promoter, leading to increased expression (31)

To detect cellular senescence in keloids, we examined SA markers

[26], and plasmids for deletion of GSH1 gene were constructed as shown in Additional file 1: Figures S1S4

It was FDA-approved in 1990 as a diagnostic agent and again in 1997 as a treatment for childhood growth hormone deficiency (brand name Geref)

These IR-induced mitochondrial defects are evident in both insulin-sensitive tissues (liver, muscle) and in the heart and brain, providing a mechanistic link between metabolic dysfunction and cardiovascularcognitive comorbidity