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Patients with diabetic retinopathy should be monitored for worsening of this condition, as rapid improvement in glucose control has been associated with temporary worsening of retinopathy

Other small studies noted symptom relief in plantar neuropathy and diabetic neuropathy when B-complex shots were used as adjunctive therapy

In patients with T2DM who are poorly controlled by metformin, increasing DUL from 1.5mg to 3.0mg or 4.5mg can provide glycosylated hemoglobin and weight loss related to clinically relevant doses and has similar safety (111)

This concentration works best for higher doses where the rounding error becomes proportionally smaller

Transplantation of Dental Pulp Stem Cells Improves Long-Term Diabetic Polyneuropathy Together with Improvement of Nerve Morphometrical Evaluation