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Perspective As indicated in the introduction, APAP has been in clinical use in the UK for over 60 years, over which time much has been learnt about its toxicity

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MSCs secrete growth factors and exosomes enriched with regulatory microRNAs (e.g., miR-21, miR-126) that inhibit apoptosis, promote angiogenesis, and activate pro-survival pathways such as PI3KAkt in injured ovaries

developed an albumin-based nanoplatform to simultaneously disrupt glucose and glutamine metabolism, addressing metabolic compensation associated with single-pathway inhibition [67]