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When free radicals outnumber antioxidants, they can cause "cellular rust," leading to premature ageing and decreased cellular function

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ROS and oxidatively modified macromolecules function as damage-associated molecular patterns (DAMPs), engaging pattern recognition receptors (PRRs) on microglia, including Toll-like receptors (TLRs) and NOD-like receptors (NLRs), to initiate inflammatory cascades ( Microglia, the resident immune cells of the CNS, are tightly regulated under physiological conditions to maintain neural homeostasis

Only a few cases due to vitamin B12 have been reported in the literature

Clonidine extended-release tablets as add-on therapy to psychostimulants in children and adolescents with ADHD