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the combination of sarcopenia and obesity (sarcopenic obesity) predicts worse outcomes than sarcopenia alone in epidemiological studies [24, 25]

42 In the STEP 1 study, participants who achieved a mean weight loss of 10.6% after 20 weeks of semaglutide were rerandomized in STEP 4 to either continue semaglutide or switch to placebo for an additional 48 weeks

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