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A prime example of intrinsic DILI is acetaminophen poisoning, also known as N Acetyl P-aminophenol (APAP) or paracetamol poisoning

[82] The name of the index is GAP and is based on gender [G], age [A], and two lung physiology variables [P] (FVC and DLCO) that are commonly measured in clinical practice to predict mortality in IPF

Targeted Interventions: For those with specific MTHFR variants, personalized interventions may be recommended, such as increased folate intake or specific B vitamin supplementation, to optimize health outcomes

Aging Cell 21 , e13589 (2022)

Mechanistically, it activates Nrf2 and its nuclear translocation, thereby enhancing the expression of downstream antioxidant genes to relieve oxidative stress