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Potential Side Effects (If Misused) While well-tolerated when dosed properly, side effects can occur if: Dose is too high Used for too long without a break Taken in a fasted or low-blood-sugar state Possible effects include: Mild hypoglycemia (shakiness, dizziness, hunger) Local injection site irritation Temporary water retention Headache or lethargy IGF-1 therapy is generally well tolerated, but dosage, duration, and patient context significantly affect side effect profiles. Cao, J

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Wiley, Hoboken, NJ, pp 209267 Gupta N, Sarkar S, David A, Gangwar PK, Gupta R, Khanna G, Sankhwar SN, Khanna A, Rajender S (2013) Significant impact of the MTHFR polymorphisms and haplotypes on male infertility risk