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It's important to recognize that this weight regain pattern reflects the chronic nature of obesity as a disease rather than treatment failure

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Lack of approval means lack of long-term safety data beyond 48 weeks, not proven danger

Proc Natl Acad Sci U S A 116:63796384

b Key inclusion criteria for the STEP 2 trial were age 18 years, type 2 diabetes diagnosed 180 days prior, BMI 27 kg/m 2 , HbA 1c 7%10% (5386 mmol/mol) and treatment with diet and exercise alone or stable treatment with metformin, sulphonylurea, sodiumglucose cotransporter2 inhibitor, glitazone as singleagent therapy or 3 agents for diabetes according to local label