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In vivo findings corroborate these results: BL administration in murine peritonitis models reduces myeloperoxidase activity, suppresses secretion of pro-inflammatory cytokines (IL-1, TNF-, and IL-6), downregulates NLRP3 and IL-1 mRNA expression in peritoneal exudate cells, and decreases protein levels of phospho-p65 and mature IL-1 (Lin et al., 2019)