glutathione production in the body Glutathione: Overview of its protective roles, measurement, and biosynthesis Glutathione is a powerful antioxidant

[DOI] [PubMed] [Google Scholar] 139.Belosic Halle Z., Vlainic J., Drmic D., Strinic D., Luetic K., Sucic M., Medvidovic-Grubisic M., Pavelic Turudic T., Petrovic I., Seiwerth S., et al

and regulates the mechanisms essential to homoeostasis, which includes enzymatic activity, protein synthesis, gene expression, and mitochondrial integrity

A study where this was investigated in hepatocytes expressing CYP2E1 in both locations or exclusively in mitochondria showed a range of adverse effects in both types of cell (despite lower cellular CYP2E1 in the latter)

ClinicalTrials.gov identifier: NCT03625648

Wang M, Liu L, Li H, Li Y, Liu H, Hou C, Zeng Q, Li P, Zhao Q, Dong L, Zhou G, Yu X, Liu L, Guan Q, Zhang S, Wang A (2020) Thyroid function, intelligence, and low-moderate fluoride exposure among Chinese school-age children