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Matsumoto D, Sato K, Gonda K, Takaki Y, Shigeura T, Sato T, Aiba-Kojima E, Iizuka F, Inoue K, Suga H, Yoshimura K

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Interestingly, elevated baseline levels of inflammatory markers such as CRP and IL-6 have been linked to both increased risk and severity of anxiety (Mac Giollabhui et al., 2025), while epidemiological data show that individuals with inflammatory autoimmune diseases like psoriasis have increased risks of experiencing developing anxiety disorders (Lee et al., 2025)

Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65