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Methylfolate bypasses the MTHFR enzyme step and is active regardless of genotype

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Some studies also suggest nicotinic acid reduces heart disease risk, but its benefits are controversial and study results have been inconsistent ( Preliminary evidence also indicates that niacin supplements may improve cognition, but further studies are needed before strong claims can be made ( Summary of Niacin Niacin, also known as vitamin B3, is a group of two related compounds niacinamide and nicotinic acid