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Miao et al., 2015

Among the 60 participants treated with GSBR-1290, only one (2.8%, from the T2DM group) discontinued the study due to drug-related adverse events (AEs)

"TRIUMPH-1 highlights the importance of options and the potential for retatrutide to help people across various stages of their obesity journey," said Kenneth Custer, Ph.D., executive vice president and president, Lilly Cardiometabolic Health

While compelling, these findings have not been independently replicated in peer-reviewed publications by other research groups

They are mitigated by: Accurate anatomical placement (deep enough into the target muscle, far enough from boundary muscles) Appropriate dilution (concentrated enough to localise but not over-concentrated) Avoiding injection too close to certain landmarks particularly the inferior border of the frontalis when treating forehead, and the inferior orbital rim when treating crows feet Patient post-treatment behaviour (not lying flat, not massaging) for the first 4 hours When complications do occur, they typically resolve as the toxin wears off over 612 weeks there is no permanent effect