Thats obviously a critical question to answer, and a new study suggests that semaglutide the generic name for Wegovy and Ozempic might increase the risk for individuals who are also taking antidepressants
Sabbadin C, Andrisani A, Zermiani M, Don G, Bordin L, Ragazzi E, Boscaro M, Ambrosini G, Armanini D (2016) Spironolactone and intermenstrual bleeding in polycystic ovary syndrome with normal BMI

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At the same time, increased knowledge of differences in drug response depending on phenotype or genetics may pave the way to more individualised therapy
beta-blockers may partially attenuate this effect