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Prior research has reported that ferroptosis participates in the remodeling of the tumor immune microenvironment and has suggested the importance of identifying novel immunotherapy targets for TNBC (44)

This metabolic sensing function extends to regulation of key metabolic enzymes such as pyruvate dehydrogenase kinase, which is inhibited by low NAD+/NADH ratios, and lactate dehydrogenase, which is activated by high NADH levels, demonstrating the sophisticated regulatory networks that depend on NAD+ redox status

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This balance helps to reduce inflammation, restore nerve cell function, and combat oxidative stress, promoting overall vitality and well-being