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Interpretation of Preclinical Models: Animal and cell models provide valuable mechanistic insights, but: Rodent biology does not always predict human responses

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*Correspondence: Yaqi Zeng [email protected] These authors have contributed equally to this work ORCID: Zhehong Shen orcid.org/0009-0002-0978-9127 Xiaotian Liu orcid.org/0009-0002-6508-720X Jun Meng orcid.org/0009-0004-4211-0870 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

In the United States, roughly 2 out of 3 adults are overweight or obese (69%) and 1 out of 3 is obese (36%)