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The catalytic activity of cIII depends on three redox-active subunits: cytochrome b (MT-CYB), the Rieske iron-sulfur [Fe2-S2] protein (UQCRFS1), and cytochrome c1 (CYC1) (Yang and Trumpower, 1986)

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GHK-Cu is exceptionally safe with minimal side effects - mild stinging at injection sites is the most common

On one hand, ROS generated by NADPH oxidase 1 (NOX1) and mitochondria can activate RIPK1 and further recruit RIPK3 to initiate necroptosis