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Medical societies recommend weight gain targets based on pre-pregnancy BMI, typically 25-35 pounds for women starting at normal weight, with adjustments for those overweight or with obesity

JMJD2A Mediates transcriptional activation of SFRP4 and regulates oxidative stress and mitochondrial dysfunction in heart failure

Meidenbauer JJ, Ta N, Seyfried TN

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This combination of increased inflammatory stimuli and reduced protective metabolites establishes a self-perpetuating cycle of barrier dysfunction, endotoxemia, oxidative stress, and liver injury