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Slovenian researchers showed that genetic variability in GLP1R is associated with inter-individual differences in the weight-lowering-lowering potential of GLP-1 drugs in obese women with polycystic ovary syndrome (PCOS) in 2015, at a time when the main GLP-1 drug was liraglutide, which required daily injection

Such circadian dampening and phase shifts are thought to contribute to health issues in the elderly

Ji, X., Wu, L., Marion, T

Some older studies examined combinations of weaker GLP-1 drugs with DPP-4 inhibitors, showing modest additional glucose lowering compared to either drug alone, but the incremental benefit did not justify the added complexity and cost for most patients

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