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Nrf2 is involved in not only the regulation of GSH synthesis and reduction via upgrading some enzymes and proteins (SLC7A11, GCLM, GCLC, GR) but also the activation of GSH-dependent antioxidant enzymes (GPX, GST) [200, 201]

Autoantibodies and B Cells: The ABC of Rheumatoid Arthritis Pathophysiology

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Together these papers provide an important update to our understanding of how cells change their metabolism when dysfunctional growth causes reactive oxygen to threaten their survival, and how those changes might influence therapeutic interventions