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There is one open-label intravenous safety pilot in two healthy adults, who received single doses of 10 mg and 20 mg with no comparator, no blinding, and short-term observation limited to vital signs, self reported symptoms and labs across two days [4]

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The 20mg/ml format ensures the daily GS-441524 dose can be drawn and administered accurately

The conversion of homocysteine to methionine reduces the potential for damage because the reaction results in the formation of the super-antioxidant glutathione