semaglutide slow weight loss Why Am I Not Losing on Semaglutide: Medical Causes Explained Woman shares journey of weight

NICE guideline NG28 recommends individualised HbA1c targets for people with type 2 diabetes, typically aiming for 48 mmol/mol (6.5%) or lower for most adults on lifestyle interventions or a single drug not associated with hypoglycaemia

The metabolic improvements from GLP-1 agonists complement hormonal therapy, providing a comprehensive approach to health

This means any unmetabolized vitamin C is excreted in the urine, so there is no benefit to over-supplementing (NIH 2025b)

When to Consider Medication Adjustments or Pauses Mild diarrhea (one to two loose stools daily) typically resolves without intervention within two to three weeks of starting semaglutide or advancing your dose

approved the drug in 2021