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Beyond MC1R, Melanotan-II's activity at MC3R and MC4R in the hypothalamus influences appetite and sexual function pathways

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These compounds have been shown to reduce the levels of pro-inflammatory cytokines (TNF-, IL-, and IL-12), inhibit NF-B p65 and IB phosphorylation, as well as modulate the TLR4 and TLR4-related pathways (NF-B and MAPK) in vitro and in vivo [237]