GIP is thought to improve insulin sensitivity in adipose tissue and to engage central satiety centers distinct from those reached by GLP-1, which is the rationale behind dual-agonist design
Int J Neuropsychopharmacol 14(1):123130 Godlewska BR, Near J, Cowen PJ (2015) Neurochemistry of major depression: a study using magnetic resonance spectroscopy
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Most of what drives your hunger and fullness is happening below the level of conscious awareness, in a biochemical conversation between your digestive system and your brain that never really stops