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The best brightening body lotions can do far more than moisturize: They tackle the whole gamut of skin concerns that can leave your arms and legs looking a little lackluster: acne scars, rough texture, keratosis pilaris (KP), bumps, dullness, and uneven tone included

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Mechanistically, this variant disrupts SP1 transcription factor binding to the JMJD3 promoter, reducing its expression in vascular smooth muscle cells (SMCs)

Further studies are needed to determine how much of the benefit comes from weight loss versus the medication itself, Thompson noted