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Statements Author contributions LZ: Writing original draft, Writing review and editing

Cycle Guidelines Common Cagrilintide Research Cycle Lengths Approach Short cycle Duration 16 weeks Review Point Week 16 Notes Reaches maintenance just as titration completes Approach Standard cycle Duration 26-32 weeks Review Point Week 26 / 32 Notes Matches Phase 2 trial durations Approach Long cycle Duration 68 weeks Review Point Week 68 Notes Matches REDEFINE 1 and REDEFINE 2 endpoints Cycle length is a research planning choice, not a treatment recommendation

doi:10.1016/j.immuni.2015.10.012

Know your limits, and stick to a set amount of drinks that you know from experience doesnt make you feel rough the next day